Glucose and lipid metabolism in insulin resistance
نویسنده
چکیده
4 LIST OF PAPERS 5 ABBREVIATIONS 6 INTRODUCTION 7 Insulin resistance 8 The role of insulin in glucose and lipid turnover 8 Insulin signalling 10 Cellular glucose transport 13 Cellular insulin resistance 14 Lipid metabolism and the adipose tissue in insulin resistance 16 Human insulin resistance and type 2 diabetes 18 Neuroendocrine and humoral factors causing insulin resistance in vivo 19 AIMS 25 METHODS 26 Animals (study I, II) 26 Patients and healthy volunteers (study III, IV) 26 Cell preparation 26 Cell culture 27 Glucose uptake 27 Insulin binding 28 Lipolysis 28 Western blot analysis of proteins in cell lysates and membranes 28 PKB phosphorylation 29 Lipoprotein lipase (LPL) and hepatic lipase (HL) 29 Blood chemistry 30 Insulin sensitivity in vivo 30 Standardized meal test 30 Statistical analyses 31 SUMMARY OF RESULTS 32 Paper I 32 Paper II 33 Paper III 33 Paper IV 35 DISCUSSION 36 Effects of glucocorticoids 36 Effects of elevated glucose and insulin concentrations 37 In vivo insulin resistance in type 2 diabetes – is glucotoxicity critical? 40 Postprandial blood lipids and lipoprotein lipase 42 SUMMARY 44 CONCLUDING REMARKS 45 POPULÄRVETENSKAPLIG SAMMANFATTNING PÅ SVENSKA 46 ACKNOWLEDGEMENTS 49 REFERENCES 50 PAPERS I-IV
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